Following an initial treatment period of up to 48 hours, LOKELMA is a once-daily option for patients not on dialysis1
RECOMMENDED STARTING DOSE
10 g
3X/DAY
FOR UP TO
48 HOURS
MAINTENANCE TREATMENT
10 g
1X/DAY
FOR UP TO
1 YEAR
- Monitor serum K+ and adjust the dose of LOKELMA based on the serum K+ level and desired target range1
- During maintenance treatment, up-titrate based on the serum K+ level at intervals of 1 week or longer and in increments of 5 g1
- The recommended maintenance dose range is from 5 g qod to 15 g daily1
- Decrease the dose of LOKELMA or discontinue if the serum K+ is below the desired target range1
qod=every other day.
For patients across all settings, LOKELMA is tasteless and odorless1,2
3 tbsp of water
HOW TO DOSE LOKELMA
- LOKELMA is a white to grey powder available as a 5 g or 10 g foil-lined packet for oral suspension1
- Administer LOKELMA orally as a suspension in water1
- Empty the entire contents of the packet(s) into a drinking glass containing approximately 3 tablespoons of water or more, if desired1
- Stir well and drink immediately1
- If powder remains in the glass, add water, stir, and drink immediately. Repeat until no powder remains1
In general, other oral medications should be administered at least 2 hours before or 2 hours after taking LOKELMA.1
Non-dialysis patients were not required to make changes in potassium-lowering diets in clinical trials2-5
- Advise patients to adjust dietary sodium, if appropriate1
Patients can take LOKELMA with or without food.1
You do not need to refrigerate LOKELMA.1
For patients on chronic hemodialysis, LOKELMA should only be dosed on non-dialysis days1
DIALYSIS DOSING
5 g
1X/DAY ON
NON-DIALYSIS
DAYS
- The recommended starting dose is 5 g once daily on non-dialysis days1
- Consider a starting dose of 10 g once daily on non-dialysis days in patients with serum K+ >6.5 mEq/L1
- Monitor serum K+ and adjust the dose of LOKELMA based on the pre-dialysis serum K+ value after the LIDI and desired target range1
- During initiation and after a dose adjustment, assess serum K+ after 1 week1
- Recommended maintenance dose range is from 5 g to 15 g once daily, on non-dialysis days1
- Discontinue or decrease the dose of LOKELMA if:
– Serum K+ falls below the desired target range based on the pre-dialysis value after the LIDI,1 or
– The patient develops clinically significant hypokalemia1
LIDI=long interdialytic interval.
For patients across all settings,
LOKELMA is tasteless and odorless1,2
3 tbsp of water
HOW TO DOSE LOKELMA
- LOKELMA is a white to grey powder available as a 5 g or 10 g foil-lined packet for oral suspension1
- Administer LOKELMA orally as a suspension in water1
- Empty the entire contents of the packet(s) into a drinking glass containing approximately 3 tablespoons of water or more, if desired1
- Stir well and drink immediately1
- If powder remains in the glass, add water, stir, and drink immediately. Repeat until no powder remains1
In general, other oral medications should be administered at least 2 hours before or 2 hours after taking LOKELMA.1
- Advise patients to adjust dietary sodium, if appropriate1