LOKELMA Dosing and Administration

Following an initial treatment period of up to 48 hours, LOKELMA is a once-daily option for patients not on dialysis1

RECOMMENDED STARTING DOSE

LOKELMA 10g sachet
LOKELMA 10g sachet

10 g

3X/DAY
FOR UP TO
48 HOURS

MAINTENANCE TREATMENT

LOKELMA 10g sachet
LOKELMA 10g sachet

10 g

1X/DAY
FOR UP TO
1 YEAR

  • Monitor serum K+ and adjust the dose of LOKELMA based on the serum K+ level and desired target range1
  • During maintenance treatment, up-titrate based on the serum K+ level at intervals of 1 week or longer and in increments of 5 g1
  • The recommended maintenance dose range is from 5 g qod to 15 g daily1
  • Decrease the dose of LOKELMA or discontinue if the serum K+ is below the desired target range1

qod=every other day.

For patients across all settings, LOKELMA is tasteless and odorless1,2

Maintenance therapy: Take one 10g packet 1x/day
Maintenance therapy: Take one 10g packet 1x/day

3 tbsp of water

Three table spoons
Three table spoons

 

HOW TO DOSE LOKELMA

  • LOKELMA is a white to grey powder available as a 5 g or 10 g foil-lined packet for oral suspension1
  • Administer LOKELMA orally as a suspension in water1
  • Empty the entire contents of the packet(s) into a drinking glass containing approximately 3 tablespoons of water or more, if desired1
  • Stir well and drink immediately1
  • If powder remains in the glass, add water, stir, and drink immediately. Repeat until no powder remains1

In general, other oral medications should be administered at least 2 hours before or 2 hours after taking LOKELMA.1

Non-dialysis patients were not required to make changes in potassium-lowering diets in clinical trials2-5

  • Advise patients to adjust dietary sodium, if appropriate1

Patients can take LOKELMA with or without food.1

You do not need to refrigerate LOKELMA.1

For patients on chronic hemodialysis, LOKELMA should only be dosed on non-dialysis days1

DIALYSIS DOSING

LOKELMA 5g sachet
LOKELMA 5g sachet

5 g

1X/DAY ON
NON-DIALYSIS
DAYS

  • The recommended starting dose is 5 g once daily on non-dialysis days1
  • Consider a starting dose of 10 g once daily on non-dialysis days in patients with serum K+ >6.5 mEq/L1
  • Monitor serum K+ and adjust the dose of LOKELMA based on the pre-dialysis serum K+ value after the LIDI and desired target range1
  • During initiation and after a dose adjustment, assess serum K+ after 1 week1
  • Recommended maintenance dose range is from 5 g to 15 g once daily, on non-dialysis days1
  • Discontinue or decrease the dose of LOKELMA if:

    – Serum K+ falls below the desired target range based on the pre-dialysis value after the LIDI,1 or

    – The patient develops clinically significant hypokalemia1

LIDI=long interdialytic interval.

For patients across all settings, 

LOKELMA is tasteless and odorless1,2

3 tbsp of water

 

HOW TO DOSE LOKELMA

  • LOKELMA is a white to grey powder available as a 5 g or 10 g foil-lined packet for oral suspension1
  • Administer LOKELMA orally as a suspension in water1
  • Empty the entire contents of the packet(s) into a drinking glass containing approximately 3 tablespoons of water or more, if desired1
  • Stir well and drink immediately1
  • If powder remains in the glass, add water, stir, and drink immediately. Repeat until no powder remains1

In general, other oral medications should be administered at least 2 hours before or 2 hours after taking LOKELMA.1

  • Advise patients to adjust dietary sodium, if appropriate1

Patients can take LOKELMA with or without food.1

You do not need to refrigerate LOKELMA.1

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