How LOKELMA works
Watch the video to find out more about LOKELMA's mechanism of action.
LOKELMA is a modern K+ binder that preferentially captures K+ and exchanges it for hydrogen and sodium.1,2 LOKELMA has a unique crystal lattice structure.2
Clinical pharmacology does not correlate with efficacy or safety.
LIMITATION OF USE: LOKELMA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.1
LOKELMA causes a small dose-dependent increase in serum bicarbonate concentrations (1.1 mEq/L at 5 g once daily, 2.3 mEq/L at 10 g once daily and 2.6 mEq/L at 15 g once daily as compared with a mean increase of 0.6 mEq/L in patients treated with placebo). The clinical significance of this finding is unclear.1
GI=gastrointestinal; qod=every other day; SPS=sodium polystyrene sulfonate.